Nordihydroguaiaretic Acid [500-38-9]

Hernández-Damián J, Andérica-Romero AC, Pedraza-Chaverri J. Paradoxical cellular effects and biological role of the multifaceted compound nordihydroguaiaretic Acid. Arch Pharm (Weinheim). 2014 Oct;347(10):685-97. PMID: 25100573. Soto-Acosta R, Bautista-Carbajal P, Syed GH, et al. Nordihydroguaiaretic acid (NDGA) inhibits replication and viral morphogenesis of dengue virus. Antiviral Res. 2014 Sep;109:132-40. PMID: 25017471. Harrison DE, Strong R, Allison DB, et al. Acarbose, 17-alfa-estradiol, and nordihydroguaiaretic acid extend mouse lifespan preferentially in males. Aging Cell. 2014 Apr;13(2):273-82. PMID: 24245565. Yang X, Cui W, Yu S, et al. A synthetic dl-nordihydroguaiaretic acid (Nordy), inhibits angiogenesis, invasion and proliferation of glioma stem cells within a zebrafish xenotransplantation model. PLoS One. 2014 Jan 15;9(1):e85759. PMID: 24454929. Szwajgier D. Anticholinesterase activity of phenolic acids and their derivatives. Z Naturforsch C. 2013 Mar-Apr;68(3-4):125-32. PMID: 23819308. Batallán G, Torre R, Flores F, et al. Larvicidal activity of crude extracts from Larrea cuneifolia (Zygophyllaceae) and of its metabolite nordihydroguaiaretic acid against the vector Culex quinquefasciatus (Diptera: Culicidae). Rev Soc Bras Med Trop. 2013 Jan-Feb;46(1):84-7. PMID: 23563831. Zhang H, Shen WJ, Cortez Y, et al. Nordihydroguaiaretic acid improves metabolic dysregulation and aberrant hepatic lipid metabolism in mice by both PPARalfa-dependent and -independent pathways. Am J Physiol Gastrointest Liver Physiol. 2013 Jan 1;304(1):G72-86. PMID: 23104557. Martino RF, Davicino RC, Mattar MA, et al. Macrophages activation by a purified fraction, free of nordihydroguaiaretic acid (NDGA), from Larrea divaricata Cav. as a potential novel therapy against Candida albicans. Immunopharmacol Immunotoxicol. 2012 Dec;34(6):975-82. PMID: 22551492. Li YJ, Kukita A, Watanabe T, et al. Nordihydroguaiaretic acid inhibition of NFATc1 suppresses osteoclastogenesis and arthritis bone destruction in rats. Lab Invest. 2012 Dec;92(12):1777-87. PMID: 23044922. Zhang Y, Xu S, Lin J, et al. mTORC1 is a target of nordihydroguaiaretic acid to prevent breast tumor growth in vitro and in vivo. Breast Cancer Res Treat. 2012 Nov;136(2):379-88. PMID: 23053656. Kim HY, Goo JH, Joo YA, et al. Impact on inflammation and recovery of skin barrier by nordihydroguaiaretic Acid as a protease-activated receptor 2 antagonist. Biomol Ther (Seoul). 2012 Sep;20(5):463-9. PMID: 24009835.