Notch1 Antibody: PerCP

Biorbyt

Notch1 Antibody: PerCP

16

1 microg/ml of SMC-430 was sufficient for detection of Notch1 in 20 microg of rat brain membrane lysate and assayed by colorimetric immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody.

ImmunoFluorescence, Western Blot, ELISA, ImmunoCytoChemistry, ImmunoHistoChemistry

WB (1:1000) ELISA, ICC, IF, IHC, WB

Research Use Only

Monoclonal

N253/32 (Formerly sold as S253-32)

1 mg/ml

PerCP

Notch1

notch 1

9930111A19Rik, Mis6, N1, Tan1, lin-12, neurogenic locus notch homolog protein 1, Motch A, Notch gene homolog 1, mT14, major type A protein, p300

Mouse

IgG1

Neurogenic locus notch homolog protein 1

Mouse monoclonal to Notch1 (PerCP). Notch is synthesized in the endoplasmic reticulum as an inactive form which is proteolytically cleaved by a furin-like convertase (S1 cleavage) in the trans-golgi network before it reaches the plasma membrane to yield an active, ligand-accessible form. Cleavage results in a C-terminal fragment N(TM) and a N-terminal fragment N(EC). Following ligand binding, it is cleaved (S2 cleavage) by TNF-alpha converting enzyme (TACE) to yield a membrane-associated intermediate fragment called Notch extracellular truncation (NEXT). This fragment is then cleaved by presenilin-dependent gamma-secretase (S3 cleavage) to release the intracellular domain (NICD) from the membrane..

Human, Mouse, Rat

See Manual

12352203