NPAS3 antibody

GeneTex

NPAS3 antibody

9

This antibody is specific for NPAS3 Internal

WB: 0.5 - 2 microg/mL. IHC-P: 5 microg/mL. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

1 mg/ml

Liquid

NPAS3

neuronal PAS domain protein 3

basic-helix-loop-helix-PAS protein MOP6; bHLHe12; class E basic helix-loop-helix protein 12; member of PAS protein 6; MOP6; neuronal PAS domain-containing protein 3; neuronal PAS3; PAS domain-containing protein 6; PASD6

Neuronal PAS domain-containing protein 3

Neuronal PAS domain protein 3 (NPAS3) is a brain-enriched basic helix-loop-helix PAS domain transcription factor and is broadly expressed in the developing neuroepithelium and has recently found to be disrupted by genetic translocation in a family affected with schizophrenia. It was recently shown to be involved in the regulation of FGF signaling in the dentate gyrus by controlling the expression of the FGF receptor subtype 1 and in turn neurogenesis emanating from this region. NPAS3- mice were growth-retarded and displayed brain defects that included reduced size of the anterior hippocampus, hypoplasia of the corpus callosum, and enlargement of the ventricles, as well as several behavioral abnormalities. Furthermore, these NPAS3- mice also exhibited disruptions in several neurosignaling pathways involving glutamate, dopamine, and serotonin. These results demonstrate the essential role played by NPAS3 during structural and functional brain development. At least three isoforms of NPAS3 are known to exist.

-20°C or -80°C,2°C to 8°C

12352203