NPD10084

MedChem Express

NPD10084

5

Research Use Only

C21H19N3O2

345.39

NPD10084 is a pyruvate kinase PKM2 inhibitor that inhibits non-glycolytic signaling in cancer cells. NPD10084 disrupts the interaction between PKM2 and beta-catenin or STAT3 and inhibits downstream signaling. NPD10084 has antiproliferative activity against colorectal cancer cells in vitro and in vivo[1].

COC1=CC=CC2=C1C=C(C(N3CCC4=C(C5=CC=CC=C5N4)C3)=O)N2

12352200