NR0B2 Polyclonal Antibody

Reddot Biotech

NR0B2 Polyclonal Antibody

5

ELISA, ImmunoHistoChemistry

Research Use Only

Polyclonal

0.6 mg/ml

Unconjugated

NR0B2

nuclear receptor subfamily 0 group B member 2

nuclear receptor SHP; nuclear receptor subfamily 0 group B member 2; orphan nuclear receptor SHP; SHP; SHP1; small heterodimer partner

Rabbit

IgG

The protein encoded by this gene is an unusual orphan receptor that contains a putative ligand-binding domain but lacks a conventional DNA-binding domain. The gene product is a member of the nuclear hormone receptor family, a group of transcription factors regulated by small hydrophobic hormones, a subset of which do not have known ligands and are referred to as orphan nuclear receptors. The protein has been shown to interact with retinoid and thyroid hormone receptors, inhibiting their ligand-dependent transcriptional activation. In addition, interaction with estrogen receptors has been demonstrated, leading to inhibition of function. Studies suggest that the protein represses nuclear hormone receptor-mediated transactivation via two separate steps: competition with coactivators and the direct effects of its transcriptional repressor function.

Human, Mouse, Rat

-20°C

12352203