NrCAM Antibody: APC

Biorbyt

NrCAM antibody

16

1 microg/ml of SMC-462 was sufficient for detection of NrCAM in 20 microg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.

ImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry

WB (1:1000), ICC/IF (1:100) ICC, IF, IHC

Research Use Only

Monoclonal

N364/51 (Formerly sold as S364-51)

1 mg/ml

APC (Allophycocyanin)

Nrcam

neuronal cell adhesion molecule

B; Bravo; C030017F07Rik; C130076O07Rik; mBravo; mKIAA0343; neuronal cell adhesion molecule; neuronal surface protein Bravo; neuron-glia-CAM-related cell adhesion molecule; ng-CAM-related; ngCAM-related cell adhesion molecule; nr-CAM

Mouse

IgG2a

Neuronal cell adhesion molecule

Mouse monoclonal to NrCAM (APC). Neuronal cell adhesion molecule (NrCAM) is a cell surface protein of the immunoglobulin (Ig) superfamily. NrCAM (also known as Bravo) contains six Ig domains, five fibronectin repeats, a transmembrane region and an intracellular domain. NrCAM is expressed in brain, spinal cord, peripheral nervous system and pancreas. In the spinal cord, NrCAM acts as a ligand for axonin-1 to guide commissural axons across the floor plate. NrCAM also acts as a ligand for F3 to control actin-dependent growth cone motility. NrCAM interacts with neurofascin and may facilitate the clustering of the cystoskeletal protein ankyrin G and the voltage-dependent sodium channel proteins at the node of Ranvier. NrCAM expression may play a role in the severity of certain types of tumors. NrCAM is overexpressed in high-grade astrocytomas, gliomas and glioblastoma tumor tissues. In the pancreas, NrCAM expression is upregulated in intraductal hyperplasia. Antisense NrCAM reduces the tumorigenic properties of human glioblastoma cells in vitro and slowed tumor growth in vivo. The gene encoding human NrCAM maps to chromosome 7q31. 1-q31. 2.

Human, Mouse, Rat

See Manual

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