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NRF1(NRF1/2608), CF405S conjugate, 0.1mg/mL [26628-22-8]

NRF1(NRF1/2608), CF405S conjugate, 0.1mg/mL [26628-22-8]

BNC042608
Biotium
ApplicationsImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityBovine, Human, Mouse
TargetNRF1
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Overview

  • Supplier
    Biotium
  • Product Name
    NRF1(NRF1/2608), CF405S conjugate, 0.1mg/mL
  • Delivery Days Customer
    9
  • Applications
    ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    NRF1/2608
  • Concentration
    0.1 mg/ml
  • Conjugate
    Other Conjugate
  • Gene ID4899
  • Target name
    NRF1
  • Target description
    nuclear respiratory factor 1
  • Target synonyms
    alpha palindromic-binding protein; ALPHA-PAL; nuclear respiratory factor 1
  • Host
    Mouse
  • Isotype
    IgG1
  • Protein IDQ16656
  • Protein Name
    Nuclear respiratory factor 1
  • Scientific Description
    The NF-E2 DNA binding protein is composed of two subunits, p45 and MafK, and it regulates expression of globin genes in developing erythroid cells through interaction with Maf recognition elements (MAREs). A family of NF-E2 related proteins, which are collectively known as the Cap n collar (CNC) family and include Nrf1 (also designated TCF11), Nrf2 and Nrf3, are bZIP transcription factors that heterodimerize with Maf proteins to bind MARE sequences. The Nrf proteins also bind the antioxidant response element (ARE) and are implicated in the regulation of detoxification enzymes and the oxidative stress response. They do so by heterodimerizing with Jun family members (c-Jun, JunB and JunD) to activate gene expression, specifically the detoxifying enzyme, NQO1. Nrf2 is widely expressed and is thought to translocate to the nucleus after treatment with xenobiotics and antioxidants, which stimulate its release from a repressor protein Keap1. Nrf3 is highly expressed in placenta, B cells and monocytes. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
  • Source
    Animal
  • Reactivity
    Bovine, Human, Mouse
  • Storage Instruction
    2°C to 8°C
  • UNSPSC
    12352203