NS13001

MedChem Express

NS13001 [1063331-94-1]

10

1063331-94-1

Research Use Only

99.62

C17H16ClN7

353.81

NS13001 is a potent, selective, orally active allosteric positive modulator of SK channels (small conductance calcium-activated potassium channels). The EC 50 s are 1.8 and 0.14 microM for SK2 and SK3, respectively. NS13001 holds promise as a potential therapeutic agent for treatment of spinocerebellar ataxia type 2 (SCA2) and possibly other cerebellar ataxias [1] .

CN1C=NC2=C(NC3=CC=C(Cl)C=C3)N=C(N4N=C(C)C=C4C)N=C12

-20°C,2°C to 8°C

12352200