NSC194598 [5358-76-9]

TargetMol Chemicals

NSC194598 [5358-76-9]

16

Chemical

Research Use Only

NSC194598

C20H19N3O

317.38

NSC194598, a p53 DNA-binding inhibitor, demonstrates an in vitro IC50 of 180 nM and an in vivo range of 2-40 microM. It disrupts the transcriptional activation of the mutated RET gene in human medullary thyroid carcinoma TT cells and is utilized in research investigating acute toxicity in normal tissues due to radiation and chemotherapy [1] [2].

3 years

O=N=1C(=NC2=CC=CC=3C=4C=CC=CC4C1C23)CN5CCCCC5

-20°C

12352200