NUAK1 Polyclonal Antibody

Reddot Biotech

NUAK1 Polyclonal Antibody

5

Western Blot

Research Use Only

1 mg/ml

Unconjugated

NUAK1

NUAK family kinase 1

AMP-activated protein kinase family member 5; AMPK-related protein kinase 5; ARK5; NUAK family SNF1-like kinase 1; NUAK family, SNF1-like kinase, 1; omphalocele kinase 1

Rabbit

IgG

NUAK family SNF1-like kinase 1also known asAMPK-related protein kinase 5(ARK5) is anenzymethat in humans is encoded by theNUAK1gene. Serine/threonine-protein kinase involved in various processes such as cell adhesion, regulation of cell ploidy and senescence, cell proliferation and tumor progression. Phosphorylates ATM, CASP6, LATS1, PPP1R12A and p53/TP53. Acts as a regulator of cellular senescence and cellular ploidy by mediating phosphorylation of Ser-464 of LATS1, thereby controlling its stability. Controls cell adhesion by regulating activity of the myosin protein phosphatase 1 (PP1) complex. Acts by mediating phosphorylation of PPP1R12A subunit of myosin PP1: phosphorylated PPP1R12A then interacts with 14-3-3, leading to reduced dephosphorylation of myosin MLC2 by myosin PP1.

Human, Rat

-20°C

12352203