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ProductsBack/Nutlin-3 [548472-68-0]

Nutlin-3 [548472-68-0]

Research Use Only
N8277
LKT Laboratories
Estimated Purity≥95%
Product group Chemicals
€ 104,00
1 mg
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Overview

  • Supplier
    LKT Laboratories
  • Product Name
    Nutlin-3 [548472-68-0]
  • Delivery Days Customer
    7
  • Certification
    Research Use Only
  • Estimated Purity
    ≥95%
  • Format
    DMSO 100 mg/mL (171.96 mM); Ethanol 30 mg/mL (51.59 mM); Water Insoluble
  • Scientific Description
    Imidzoline derivative; MDM2 inhibitor.; Nutlin3
  • Storage Instruction
    -20°C
  • UNSPSC
    12352200

References

  • Shi X, Liu J, Ren L, et al. Nutlin-3 downregulates p53 phosphorylation on serine(392) and induces apoptosis in hepatocellular carcinoma cells. BMB Rep. 2014 Apr;47(4):221-6. PMID: 24286312. Choe YJ, Lee SY, Ko KW, et al. Nutlin-3 induces HO-1 expression by activating JNK in a transcription-independent manner of p53. Int J Oncol. 2014 Mar;44(3):761-8. PMID: 24366007. Wu Y, Fu Y, Zheng L, et al. Nutlin-3 inhibits epithelial-mesenchymal transition by interfering with canonical transforming growth factor-bèta1-Smad-Snail/Slug axis. Cancer Lett. 2014 Jan 1;342(1):82-91. PMID: 24001610. Secchiero P, Toffoli B, Melloni E, et al. The MDM2 inhibitor Nutlin-3 attenuates streptozotocin-induced diabetes mellitus and increases serum level of IL-12p40. Acta Diabetol. 2013 Dec;50(6):899-906. PMID: 23615706. Tisato V, Norcio A, Voltan R, et al. MDM2 non-genotoxic inhibitors as innovative therapeutic approaches for the treatment of pediatric malignancies. Curr Med Chem. 2013;20(17):2226-36. PMID: 23458617.