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ProductsBack/NVP-AEW541 [475489-16-8]

NVP-AEW541 [475489-16-8]

Research Use Only
N8561
LKT Laboratories
Estimated Purity≥98%
Product group Chemicals
€ 214,00
5 mg
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Overview

  • Supplier
    LKT Laboratories
  • Product Name
    NVP-AEW541 [475489-16-8]
  • Delivery Days Customer
    7
  • Certification
    Research Use Only
  • Estimated Purity
    ≥98%
  • Format
    DMSO 88 mg/mL (200.2 mM); Water Insoluble; Ethanol Insoluble
  • Scientific Description
    IGF-1R inhibitor.; AEW-541
  • Storage Instruction
    -20°C
  • UNSPSC
    12352200

References

  • Rubinfeld H, Kammer A, Cohen O, et al. IGF1 induces cell proliferation in human pituitary tumors - Functional blockade of IGF1 receptor as a novel therapeutic approach in non-functioning tumors. Mol Cell Endocrinol. 2014 Apr 24;390(1-2):93-101. [Epub ahead of print]. PMID: 24769281. Ioannou N, Seddon AM, Dalgleish A, et al. Treatment with a combination of the ErbB (HER) family blocker afatinib and the IGF-IR inhibitor, NVP-AEW541 induces synergistic growth inhibition of human pancreatic cancer cells. BMC Cancer. 2013 Jan 31;13:41. PMID: 23367880. Isebaert SF, Swinnen JV, McBride WH, et al. Insulin-like growth factor-type 1 receptor inhibitor NVP-AEW541 enhances radiosensitivity of PTEN wild-type but not PTEN-deficient human prostate cancer cells. Int J Radiat Oncol Biol Phys. 2011 Sep 1;81(1):239-47. PMID: 21816290. Premkumar DR, Jane EP, Pollack IF. Co-administration of NVP-AEW541 and dasatinib induces mitochondrial-mediated apoptosis through Bax activation in malignant human glioma cell lines. Int J Oncol. 2010 Sep;37(3):633-43. PMID: 20664932.