NVP-BEZ235 [915019-65-7]

Biorbyt

NVP-BEZ235 [915019-65-7]

16

915019-65-7

Research Use Only

C30H23N5O

469.5365

BEZ235 (NVP-BEZ235) is a dual ATP-competitive PI3K and mTOR inhibitor of p110alpha, p110gamma, p110delta and p110beta with IC50 of 4 nM, 5 nM, 7 nM and 75 nM, respectively, and also inhibits ATR with IC50 of 21 nM.

O=C1N(C([H])([H])[H])C2=C([H])N=C3C([H])=C([H])C(C4C([H])=NC5=C([H])C([H])=C([H])C([H])=C5C=4[H])=C([H])C3=C2N1C1C([H])=C([H])C(=C([H])C=1[H])C(C#N)(C([H])([H])[H])C([H])([H])[H]

12352200