NVP-TAE684 [761439-42-3]
N8760
Overview
- SupplierLKT Laboratories
- Product NameNVP-TAE684 [761439-42-3]
- Delivery Days Customer7
- Estimated Purity≥98%
- FormatDMSO 3 mg/mL (4.88 mM); Water Insoluble; Ethanol Insoluble
- Scientific DescriptionALK, c-Fes, LRRK2 inhibitor.; TAE684
- Storage Instruction-20°C
- UNSPSC12352200
References
- Hellwig S, Miduturu CV, Kanda S, et al. Small-molecule inhibitors of the c-Fes protein-tyrosine kinase. Chem Biol. 2012 Apr 20;19(4):529-40. PMID: 22520759. Zhang J, Deng X, Choi HG, et al. Characterization of TAE684 as a potent LRRK2 kinase inhibitor. Bioorg Med Chem Lett. 2012 Mar 1;22(5):1864-9. PMID: 22335897. Cerchietti L, Damm-Welk C, Vater I, et al. Inhibition of anaplastic lymphoma kinase (ALK) activity provides a therapeutic approach for CLTC-ALK-positive human diffuse large B cell lymphomas. PLoS One. 2011 Apr 8;6(4):e18436. PMID: 21494621. Galkin AV, Melnick JS, Kim S, et al. Identification of NVP-TAE684, a potent, selective, and efficacious inhibitor of NPM-ALK. Proc Natl Acad Sci U S A. 2007 Jan 2;104(1):270-5. Erratum in: Proc Natl Acad Sci U S A. 2007 Feb 6;104(6):2025. PMID: 17185414.