O-Desmethyl gefitinib-d6

MedChem Express

O-Desmethyl gefitinib-d6

10

Research Use Only

C21H16D6ClFN4O3

438.91

O-Desmethyl gefitinib-d 6 is the deuterium labeled O-Desmethyl gefitinib. O-Desmethyl gefitinib is an active metabolite of Gefitinib in human plasma. The formation of O-desmethyl gefitinib is dependent on CYP2D6 activity. O-desmethyl gefitinib inhibits EGFR with an IC50 of 36 nM in subcellular assays[1][2].

OC1=CC2=NC=NC(NC3=CC=C(F)C(Cl)=C3)=C2C=C1OC([2H])([2H])C([2H])([2H])C([2H])([2H])N4CCOCC4

12352200