O-Desmethyl gefitinib-d8

MedChem Express

O-Desmethyl gefitinib-d8

10

Research Use Only

99.84

C21H14D8ClFN4O3

440.93

O-Desmethyl gefitinib-d 8 is a deuterium labeled O-Desmethyl gefitinib. O-Desmethyl gefitinib is an active metabolite of Gefitinib in human plasma. The formation of O-desmethyl gefitinib is dependent on CYP2D6 activity. O-desmethyl gefitinib inhibits EGFR with an IC50 of 36 nM in subcellular assays[1][2].

OC1=CC2=NC=NC(NC3=CC=C(F)C(Cl)=C3)=C2C=C1OCCCN4C([2H])([2H])C([2H])([2H])OC([2H])([2H])C4([2H])[2H]

-20°C,2°C to 8°C

12352200