O-Desmethyl Midostaurin [740816-86-8]

MedChem Express

O-Desmethyl Midostaurin [740816-86-8]

9

740816-86-8

Research Use Only

95.48

C34H28N4O4

556.61

O-Desmethyl Midostaurin (CGP62221; O-Desmethyl PKC412) is the active metabolite of Midostaurin (HY-10230) via cytochrome P450 liver enzyme metabolism. O-Desmethyl Midostaurin can be used as an indicator for Midostaurin metabolism in vivo[1]. Midostaurin is a multi-targeted protein kinase inhibitor with IC50 ranging from 22-500 nM.

O=C(N([C@@H]1C[C@]([H])(N2C3=C4C=CC=C3)O[C@](C)(N5C6=C2C4=C(C(NC7)=O)C7=C6C8=C5C=CC=C8)[C@@H]1O)C)C9=CC=CC=C9

-20°C,2°C to 8°C

12352200