O6BTG-C8-alphaGlu [793035-88-8]

MedChem Express

O6BTG-C8-alphaGlu [793035-88-8]

5

793035-88-8

Research Use Only

C24H34BrN5O7S

616.53

O6BTG-C8-alphaGlu is an O6-methylguanine-DNA methyltransferase (MGMT) inhibitor with an IC50 of 0.45 microM. At a concentration of 0.1 microM, O6BTG-C8-alphaGlu can completely inhibit MGMT in HeLaS3 cells. Even when applied chronically at high doses (up to 20 microM), it does not exhibit cytotoxicity. O6BTG-C8-alphaGlu is suitable for research on MGMT-related cancer diseases[1].

BrC1=CSC(COC2=C3C(N(C=N3)CCCCCCCCO[C@H]4O[C@@H]([C@H]([C@@H]([C@H]4O)O)O)CO)=NC(N)=N2)=C1

12131703