OAS3 Antibody, Biotin conjugated

Cusabio

OAS3 Antibody, Biotin conjugated

20

ELISA

Research Use Only

Polyclonal

Biotin

Liquid

OAS3

2'-5'-oligoadenylate synthetase 3

(2-5')oligo(A) synthase 3; (2-5')oligo(A) synthetase 3; 2-5A synthase 3; 2-5A synthetase 3; 2'-5'-oligoadenylate synthase 3; 2'-5'-oligoadenylate synthetase 3, 100kDa; 2'-5'oligoadenylate synthetase p100; p100; p100 OAS; p100OAS

Rabbit

IgG

2'-5'-oligoadenylate synthase 3

Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes preferentially dimers of 2\-5\-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L. Displays antiviral activity against Chikungunya virus (CHIKV), Dengue virus, Sindbis virus (SINV) and Semliki forest virus (SFV).

Human

-20°C or -80°C

12352203