![Occludin (OCLN) (Tight Junctions Marker)(OCLN/2183), CF405S conjugate, 0.1mg/mL [26628-22-8] Occludin (OCLN) (Tight Junctions Marker)(OCLN/2183), CF405S conjugate, 0.1mg/mL [26628-22-8]](https://biotium.com/wp-content/uploads/2021/02/view_image-646.jpeg)
Occludin (OCLN) (Tight Junctions Marker)(OCLN/2183), CF405S conjugate, 0.1mg/mL [26628-22-8]
BNC042183
ApplicationsImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityBovine, Human, Mouse
TargetOCLN
Overview
- SupplierBiotium
- Product NameOccludin (OCLN) (Tight Junctions Marker)(OCLN/2183), CF405S conjugate, 0.1mg/mL
- Delivery Days Customer9
- ApplicationsImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone IDOCLN/2183
- Concentration0.1 mg/ml
- ConjugateOther Conjugate
- Gene ID100506658
- Target nameOCLN
- Target descriptionoccludin
- Target synonymsBLCPMG; occludin; phosphatase 1, regulatory subunit 115; PPP1R115; PTORCH1
- HostMouse
- IsotypeIgG1
- Protein IDQ16625
- Protein NameOccludin
- Scientific DescriptionOccludin is a tetraspan integral membrane protein in epithelial and endothelial tight junction (TJ) structures that can contain two extracellular loops. The protein exists in a variety of phosphorylated forms. Phosphorylation is involved in regulating both the localization and the function of Occludin. Expression of Occludin is upregulated by polyunsaturated fatty acids, increasing trans-endothelial cell resistance and reducing cellular permeability to large molecules. The level of Occludin varies greatly depending on tissue; in brain tissue, Occludin is highly expressed at cell-cell contact sites. Non-neural tissues show lower expression and discontinuous distribution. Up-regulation of epithelial Occludin may play a role in enhancing paracellular permeability and be related to the damage to the tight junction. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
- SourceAnimal
- ReactivityBovine, Human, Mouse
- Storage Instruction2°C to 8°C
- UNSPSC12352203