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ProductsBack/OM173-alphaA [58286-56-9]
Chemical Structure
Chemical Structure
Chemical Structure

OM173-alphaA [58286-56-9]

Research Use Only
AG-CN2-0158
AdipoGen Life Sciences
CAS Number58286-56-9
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Product group Chemicals
Estimated Purity>95% (HPLC)
Molecular Weight316.3
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Overview

  • Supplier
    AdipoGen Life Sciences
  • Product Name
    OM173-alphaA [58286-56-9]
  • Delivery Days Customer
    10
  • CAS Number
    58286-56-9
  • Certification
    Research Use Only
  • Estimated Purity
    >95% (HPLC)
  • Hazard Information
    Non-hazardous,Warning
  • Molecular Formula
    C17H16O6
  • Molecular Weight
    316.3
  • Scientific Description
    Antibiotic [1-3]. Antimycoplasma [1, 3, 4]. Antifungal compound [1, 3]. Anti-malarial agent [5]. Ras-competitive non-CAAX mimetic type farnesyltransferase (FTase) inhibitor [6]. Potential anticancer compound. Inducer of antiproliferative effects in tumor cell lines [6-8]. Selective DNA (cytosine-5)-methyltransferase 3B (DNMT3B) inhibitor [8]. - Chemical. CAS: 58286-56-9. Formula: C17H16O6. MW: 316.3. Isolated from Streptomyces sp. Antibiotic. Antimycoplasma. Antifungal compound. Anti-malarial agent. Ras-competitive non-CAAX mimetic type farnesyltransferase (FTase) inhibitor. Potential anticancer compound. Inducer of antiproliferative effects in tumor cell lines. Selective DNA (cytosine-5)-methyltransferase 3B (DNMT3B) inhibitor.
  • SMILES
    COC(=O)C[C@H]1CC2=C([C@H](C)O1)C(=O)C1=C(O)C=CC=C1C2=O
  • Storage Instruction
    2°C to 8°C,-20°C
  • UNSPSC
    12352200

References

  • Nanaomycins, new antibiotics produced by a strain of Streptomyces. I. Taxonomy, isolation, characterization and biological properties: H. Tanaka, et al.; J. Antibiot. 28, 860 (1975)
  • Nanomycins, new antibiotics produced by a strain of Streptomyces. II. Structure and biosynthesis: H. Tanaka, et al.; J. Antibiot. 28, 868 (1975)
  • Nanaomycins, new antibiotics produced by a strain of Streptomyces. III. A new component, nanaomycin C, and biological activities of nanaomycin derivatives: H. Tanaka, et al.; J. Antibiot. 28, 925 (1975)
  • OM-173, new nanaomycin-type antibiotics produced by a strain of Streptomyces. Taxonomy, production, isolation and biological properties: Y. Iway, et al.; J. Antibiot. 36, 1268 (1983)
  • Heme-dependent radical generation: possible involvement in antimalarial action of non-peroxide microbial metabolites, nanaomycin A and radicicol: Y. Tanaka, et al.; J. Antibiot. 52, 880 (1999)
  • UCF76 compounds, new inhibitors of farnesyltransferase produced by Streptomyces: M. Hara, et al.; J. Antibiot. 54, 182 (2001)
  • Total synthesis and development of bioactive natural products: T. Kuniaki; Proc. Jpn. Acad. Ser. B. Phys. Biol. Sci. 84, 87 (2008)
  • Nanaomycin A selectively inhibits DNMT3B and reactivates silenced tumor suppressor genes in human cancer cells: D. Kuck, et al.; Mol. Cancer Ther. 9, 3015 (2010)