Omipalisib (GSK-458)

Biorbyt

Omipalisib (GSK-458) [1086062-66-9]

16

1086062-66-9

Research Use Only

C25H17F2N5O3S

505.496

GSK2126458 is a highly selective and potent inhibitor of PI3K with Ki of 0.019 nM/0.13 nM/0.024 nM/0.06 nM and 0.18 nM/0.3 nM for p110alpha/beta/delta/gamma, mTORC1/2 , respectively.

S(C1C([H])=C([H])C(=C([H])C=1F)F)(N([H])C1=C(N=C([H])C(=C1[H])C1C([H])=C([H])C2C(=C(C([H])=C([H])N=2)C2=C([H])N=NC([H])=C2[H])C=1[H])OC([H])([H])[H])(=O)=O

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