Ophiobolin A [4611-05-6]

Bury M, Novo-Uzal E, Andolfi A, et al. Ophiobolin A, a sesterterpenoid fungal phytotoxin, displays higher in vitro growth-inhibitory effects in mammalian than in plant cells and displays in vivo antitumor activity. Int J Oncol. 2013; 43(2):575-85. PMID: 23754298. Bury M, Girault A, Mégalizzi V, et al. Ophiobolin A induces paraptosis-like cell death in human glioblastoma cells by decreasing BKCa channel activity. Cell Death Dis. 2013, 28;4:e561. PMID: 23538442 Dasari R, Masi M, Lisy R, et al. Fungal metabolite ophiobolin A as a promising anti-glioma agent: In vivo evaluation, structure-activity relationship and unique pyrrolylation of primary amines. Bioorg Med Chem Lett. 2015, 25(20):4544-8. PMID: 26341136, Chidley C, Trauger SA, Birsoy K, O'Shea EK. The anticancer natural product ophiobolin A induces cytotoxicity by covalent modification of phosphatidylethanolamine. Elife. 2016;5. pii: e14601. PMID: 27403889. Rodolfo C, Rocco M, Cattaneo L, Ophiobolin A Induces Autophagy and Activates the Mitochondrial Pathway of Apoptosis in Human Melanoma Cells. PLoS One. 2016;11(12):e0167672. PMID: 27936075