Ophiobolin A

Bioss Antibodies

Ophiobolin A

16

Research Use Only

>95%

Cell permeable, irreversible calmodulin antagonist. Acts by covalently binding to a lysine-rich inhibitory site. Inhibits by blocking the activation of the Ca2+/calmodulin-dependent phosphodiesterase [1-3, 5, 6, 9]. Herbicidal mycotoxin [7]. Phytotoxic, antifungal, antibacterial and nematocidal compound [4, 6, 10]. Anticancer compound. Shown to induce paraptosis-like cell death [11, 12]. Shown to inhibit P-glycoprotein-mediated transport [8]. Disruptor of intracellular sulfhydryl proteostasis, leading to ER stress and dilation.

-20°C

51202000