ORC1 Antibody / Origin Recognition Complex 1
ORB639845
ApplicationsELISA
Product group Antibodies
Overview
- SupplierBiorbyt
- Product NameORC1 Antibody / Origin Recognition Complex 1
- Delivery Days Customer16
- ApplicationsELISA
- Applications SupplierELISA (order BSA-free format for coating) ELISA
- CertificationResearch Use Only
- Clone ID7F6/1
- IsotypeIgG
- Scientific DescriptionThe initiation of DNA replication is a multi-step process that depends on the formation of pre-replication complexes, which trigger initiation. Among the proteins required for establishing these complexes are the origin recognition complex (ORC) proteins. ORC proteins bind specifically to origins of replication where they serve as scaffold for the assembly of additional initiation factors. Human ORC subunits 1-6 are expressed in the nucleus of proliferating cells and tissues, such as the testis. ORC1 and ORC2 are both expressed at equivalent concentrations throughout the cell cycle; however, only ORC2 remains stably bound to chromatin. ORC4 and ORC6 are also expressed constantly throughout the cell cycle. ORC2, ORC3, ORC4 and ORC5 form a core complex upon which ORC6 and ORC1 assemble. The formation of this core complex suggests that ORC proteins play a crucial role in the G1-S transition in mammalian cells.
- UNSPSC12352203