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ProductsBack/OSBP Antibody, Biotin conjugated

OSBP Antibody, Biotin conjugated

CSB-PA017254LD01HU
Cusabio
ApplicationsELISA
Product group Antibodies
ReactivityHuman
TargetOSBP
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Overview

  • Supplier
    Cusabio
  • Product Name
    OSBP Antibody, Biotin conjugated
  • Delivery Days Customer
    20
  • Applications
    ELISA
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Conjugate
    Biotin
  • Gene ID5007
  • Target name
    OSBP
  • Target description
    oxysterol binding protein
  • Target synonyms
    OSBP1; oxysterol-binding protein 1
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDP22059
  • Protein Name
    Oxysterol-binding protein 1
  • Scientific Description
    Lipid transporter involved in lipid countertransport between the Golgi complex and membranes of the endoplasmic reticulum: specifically exchanges sterol with phosphatidylinositol 4-phosphate (PI4P), delivering sterol to the Golgi in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum (PubMed:24209621). Binds cholesterol and a range of oxysterols including 25-hydroxycholesterol (PubMed:15746430, PubMed:17428193). Cholesterol binding promotes the formation of a complex with PP2A and a tyrosine phosphatase which dephosphorylates ERK1/2, whereas 25-hydroxycholesterol causes its disassembly (PubMed:15746430). Regulates cholesterol efflux by decreasing ABCA1 stability (PubMed:18450749).
  • Reactivity
    Human
  • Storage Instruction
    -20°C or -80°C
  • UNSPSC
    12352203