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ProductsBack/OSI-906 [867160-71-2]

OSI-906 [867160-71-2]

Research Use Only
O7333
LKT Laboratories
Estimated Purity≥98%
Product group Chemicals
€ 141,00
5 mg
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Overview

  • Supplier
    LKT Laboratories
  • Product Name
    OSI-906 [867160-71-2]
  • Delivery Days Customer
    7
  • Certification
    Research Use Only
  • Estimated Purity
    ≥98%
  • Format
    DMSO 84 mg/mL (199.29 mM); Water Insoluble; Ethanol Insoluble
  • Scientific Description
    IGF-1R and InsR inhibitor.; OSI906, Linsitinib
  • Storage Instruction
    -20°C
  • UNSPSC
    12352200

References

  • Bendell JC, Jones SF, Hart L, et al. A phase Ib study of linsitinib (OSI-906), a dual inhibitor of IGF-1R and IR tyrosine kinase, in combination with everolimus as treatment for patients with refractory metastatic colorectal cancer. Invest New Drugs. 2015 Feb;33(1):187-93. PMID: 25335932. Rao W, Li H, Song F, et al. OVA66 increases cell growth, invasion and survival via regulation of IGF-1R-MAPK signaling in human cancer cells. Carcinogenesis. 2014 Jul;35(7):1573-81. PMID: 24667688. Mulvihill MJ, Cooke A, Rosenfeld-Franklin M, et al. Discovery of OSI-906: a selective and orally efficacious dual inhibitor of the IGF-1 receptor and insulin receptor. Future Med Chem. 2009 Sep;1(6):1153-71. PMID: 21425998.