More than 130 suppliers
ISO certified
In-house tech support
we Connect you
Bio-Connect
ProductsBack/Osthole [484-12-8]
Chemical Structure
Chemical Structure
Chemical Structure

Osthole [484-12-8]

Research Use Only
CDX-O0097
Chemodex
CAS Number484-12-8
DownloadDatasheet
Product group Chemicals
Estimated Purity>95%
Molecular Weight244.29
Price on request
Packing Size
Large volume orders?
Order with a bulk request
More than 130 suppliers
ISO certified
In-house tech support

Overview

  • Supplier
    Chemodex
  • Product Name
    Osthole [484-12-8]
  • Delivery Days Customer
    10
  • CAS Number
    484-12-8
  • Certification
    Research Use Only
  • Estimated Purity
    >95%
  • Molecular Formula
    C15H16O3
  • Molecular Weight
    244.29
  • Scientific Description
    Chemical. CAS: 484-12-8. Formula: C15H16O3. MW: 244.29. Synthetic. Osthole is a natural coumarin that was first isolated from several medicinal plants, including C. monnieri and A. pubescens. Osthole exhibits immunomodulatory, antioxidative, and anti-inflammatory properties, by regulating the expression of TNF-alpha, NF-kappaB, TGF-beta, cyclooxygenases, leukotrienes, nitric oxide, ERK and JNK. Shows also anti-cancer, chemopherapeutic, analgesic, neuroprotective, antipruritic, anti-leishmania and anti-lipedemic activities. It is reported to induce a nonspecific elevation of cAMP and cGMP levels through its ability to inhibit phosphodiesterases, which leads to a modulation of calcium channel signaling and vasorelaxant effects. Selectively inhibits TRPV3 channels in skin. Induces apoptosis and cell cycle arrest in cancer cells. Suppression of fatty acid synthase expression in HER2-overexpressing breast cancer cells indicates osthole as a promising agent for chemotherapy. - Osthole is a natural coumarin that was first isolated from several medicinal plants, including C. monnieri and A. pubescens. Osthole exhibits immunomodulatory, antioxidative, and anti-inflammatory properties, by regulating the expression of TNF-alpha, NF-kappaB, TGF-beta, cyclooxygenases, leukotrienes, nitric oxide, ERK and JNK. Shows also anti-cancer, chemopherapeutic, analgesic, neuroprotective, antipruritic, anti-leishmania and anti-lipedemic activities. It is reported to induce a nonspecific elevation of cAMP and cGMP levels through its ability to inhibit phosphodiesterases, which leads to a modulation of calcium channel signaling and vasorelaxant effects. Selectively inhibits TRPV3 channels in skin. Induces apoptosis and cell cycle arrest in cancer cells. Suppression of fatty acid synthase expression in HER2-overexpressing breast cancer cells indicates osthole as a promising agent for chemotherapy.
  • SMILES
    O=C1OC2=C(C/C=C(C)/C)C(OC)=CC=C2C=C1
  • Storage Instruction
    RT
  • UNSPSC
    12352200