OTS193320

MedChem Express

OTS193320

10

Research Use Only

99.08

C28H30ClN5O4

536.02

OTS193320, a imidazo[1,2-a]pyridine compound, is a SUV39H2 methyltransferase activity inhibitor. OTS193320 decreases global histone H3 lysine 9 tri-methylation levels in breast cancer cells and triggers apoptotic cell death. Combination of OTS193320 with Doxorubicin (DOX; HY-15142A) results in reduction of gamma-H2AX levels as well as cancer cell viability compared to a single agent OTS193320 or DOX [1] .

O=[N+](C1=CC=C(CN[C@@H]2CC[C@H](NC3=CC4=NC(C5=CC(Cl)=C(OC)C=C5OC)=CN4C=C3)CC2)C=C1)[O-]

-20°C

12352200