OTUB1 antibody

GeneTex

OTUB1 antibody

9

WB: 1:500-1:3000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

Western Blot

Research Use Only

Polyclonal

0.26 mg/ml

Unconjugated

Otub1

OTU domain, ubiquitin aldehyde binding 1

AI850305; deubiquitinating enzyme OTUB1; OTU domain-containing ubiquitin aldehyde-binding protein 1; otubain 1; ubiquitin thioesterase OTUB1; ubiquitin-specific-processing protease OTUB1

Rabbit

IgG

Ubiquitin thioesterase OTUB1

Hydrolase that can remove conjugated ubiquitin from proteins in vitro and may therefore play an important regulatory role at the level of protein turnover by preventing degradation. Regulator of T-cell anergy, a phenomenon that occurs when T-cells are rendered unresponsive to antigen rechallenge and no longer respond to their cognate antigen. Acts via its interaction with RNF128/GRAIL. Surprisingly, it regulates RNF128-mediated ubiquitination, but does not deubiquitinate polyubiquitinated RNF128. Deubiquitinates estrogen receptor alpha (ESR1). Mediates deubiquitination of Lys-48-linked polyubiquitin chains, but not Lys-63-linked polyubiquitin chains. Not able to cleave di-ubiquitin. Also capable of removing NEDD8 from NEDD8 conjugates, but with a nuch lower preference compared to Lys-48-linked ubiquitin.

Mouse, Rat

-20°C or -80°C,2°C to 8°C

12352203