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P16 Monoclonal Antibody

RD6909
Reddot Biotech
ApplicationsImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
TargetCDKN2A
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Overview

  • Supplier
    Reddot Biotech
  • Product Name
    P16 Monoclonal Antibody
  • Delivery Days Customer
    5
  • Applications
    ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Concentration
    100 ug/ml
  • Gene ID1029
  • Target name
    CDKN2A
  • Target description
    cyclin dependent kinase inhibitor 2A
  • Target synonyms
    alternative reading frame; ARF; CDK4 inhibitor p16-INK4; CDK4I; CDKN2; cell cycle negative regulator beta; CMM2; cyclin-dependent kinase 4 inhibitor A; cyclin-dependent kinase inhibitor 2A; cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4); INK4; INK4A; MLM; MTS1; MTS-1; multiple tumor suppressor 1; P14; P14ARF; P16; P16INK4; P16INK4A; P16-INK4A; P19; P19ARF; TP16
  • Host
    Mouse
  • Scientific Description
    P16, also known as mitosis inhibitor, is one of the cell cycle regulatory proteins. It competitively binds to CDK4 / 6 with cyclin D, prevents cells entering to S phase from G1 phase, it is negatively regulating mitosis. In tumor cells, p16 expression is often increased due to gene mutation or deletion. P16 is closely related to cervical cancer caused by HPV infection. P16 is overexpressed in high-risk squamous epithelium injury (HSIL). p16 expression in low-risk squamous epithelium injury (LSIL) is Weak or medium, while there is no p16 expression in normal cervical epithelium. Therefore, p16 is helpful to study the grading of cervical epithelial neoplasia.
  • UNSPSC
    12352203