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IHC-P analysis of bladder carcinoma tissue using GTX34926 p21 Cip1 antibody [WA-1].
IHC-P analysis of bladder carcinoma tissue using GTX34926 p21 Cip1 antibody [WA-1].
IHC-P analysis of bladder carcinoma tissue using GTX34926 p21 Cip1 antibody [WA-1].

p21 Cip1 antibody [WA-1]

Research Use Only
GTX34926
GeneTex
ApplicationsFlow Cytometry, ImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman, Monkey, Mouse, Primate, Rat
TargetCDKN1A
Price on request
Packing Size
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Overview

  • Supplier
    GeneTex
  • Product Name
    p21 Cip1 antibody [WA-1]
  • Delivery Days Customer
    9
  • Antibody Specificity
    This MAb recognizes a 21kDa protein, identified as the p21WAF1 tumor suppressor protein. This MAb is highly specific to p21 and shows no cross-reaction with other closely related mitotic inhibitors.
  • Applications
    Flow Cytometry, ImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    WA-1
  • Concentration
    0.2 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID1026
  • Target name
    CDKN1A
  • Target description
    cyclin dependent kinase inhibitor 1A
  • Target synonyms
    CAP20; CDK-interacting protein 1; CDK-interaction protein 1; CDKN1; CIP1; cyclin-dependent kinase inhibitor 1; cyclin-dependent kinase inhibitor 1A (p21, Cip1); DNA synthesis inhibitor; MDA-6; melanoma differentiation associated protein 6; P21; p21CIP1; SDI1; WAF1; wild-type p53-activated fragment 1
  • Host
    Mouse
  • Isotype
    IgG1
  • Scientific Description
    This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-cyclin-dependent kinase2 or -cyclin-dependent kinase4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen, a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of cyclin-dependent kinase2, and may be instrumental in the execution of apoptosis following caspase activation. Mice that lack this gene have the ability to regenerate damaged or missing tissue. Multiple alternatively spliced variants have been found for this gene. [provided by RefSeq, Sep 2015]
  • Reactivity
    Human, Monkey, Mouse, Primate, Rat
  • Storage Instruction
    2°C to 8°C,-20°C or -80°C
  • UNSPSC
    12352203