P22077 [1247819-59-5]
27712
CAS Number1247819-59-5
Product group Chemicals
Estimated Purity≥98%
Molecular Weight315.3 Da
Overview
- SupplierBPS Bioscience
- Product NameP22077 [1247819-59-5]
- Delivery Days Customer7
- CAS Number1247819-59-5
- CertificationResearch Use Only
- Estimated Purity≥98%
- Molecular FormulaC12H7F2NO3S2
- Molecular Weight315.3 Da
- Scientific DescriptionP22077 is a cell permeable inhibitor of the ubiquitin-specific protease USP7 (IC50=8.6 microM), and the closely related deubiquitinase (DUB) USP47. P22077 showed weak or no inhibition (EC50 >50microM) towards a panel of 14 isopeptidases and other proteases. Treatment of cells with P22077 (20-40 microM) causes an accumulation of K48-linked ubiquitinated species, and down regulation of the USP7 targets HDM2 and claspin.
- UNSPSC12352200