p38-alpha MAPK-IN-5

MedChem Express

p38-alpha MAPK-IN-5

10

Research Use Only

C37H49N11O2

679.86

p38-alpha MAPK-IN-5 (compound 4e) is a potent p38alpha inhibitor with IC50s of 0.1 nM, 0.2 nM, 944 nM, 4100 nM for p38alpha, p38 beta, p38gamma, p38delta, respectively. p38-alpha MAPK-IN-5 has anti-inflammatory effect. p38-alpha MAPK-IN-5 has the potential for asthma and chronic obstructive pulmonary disease (COPD) research[1].

O=C(N[C@H]1CC[C@H](C2=C1C=CC=C2)OC(C=C3)=CN4C3=NN=C4N5[C@H](CCCC5)C)NC6=CC(C(C)(C)C)=NN6C7=CN(N=C7)CCN(C)C

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