ICC/IF analysis of paraformaldehyde fixed A431 cells using GTX89145 P4HA1 antibody, Internal. Green : Primary antibody Blue : DAPI Negative control: Unimmunized goat IgG Dilution : 10microg/ml
P4HA1 antibody, Internal
GTX89145
ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman, Rat
TargetP4HA1
Overview
- SupplierGeneTex
- Product NameP4HA1 antibody, Internal
- Delivery Days Customer9
- Antibody SpecificityThis antibody is expected to recognise both reported isoforms (NP_000908.2 and NP_001017962.1).
- ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityPolyclonal
- Concentration0.50 mg/ml
- ConjugateUnconjugated
- Gene ID5033
- Target nameP4HA1
- Target descriptionprolyl 4-hydroxylase subunit alpha 1
- Target synonymscollagen prolyl 4-hydroxylase alpha(I); C-P4Halpha(I); P4HA; procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide I; procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-1; prolyl 4-hydroxylase subunit alpha-1; prolyl 4-hydroxylase, alpha polypeptide I
- HostGoat
- IsotypeIgG
- Scientific DescriptionThis gene encodes a component of prolyl 4-hydroxylase, a key enzyme in collagen synthesis composed of two identical alpha subunits and two beta subunits. The encoded protein is one of several different types of alpha subunits and provides the major part of the catalytic site of the active enzyme. In collagen and related proteins, prolyl 4-hydroxylase catalyzes the formation of 4-hydroxyproline that is essential to the proper three-dimensional folding of newly synthesized procollagen chains. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
- ReactivityHuman, Rat
- Storage Instruction2°C to 8°C,-20°C or -80°C
- UNSPSC12352203
References
- Overexpression of P4HA1 associates with poor prognosis and promotes cell proliferation and metastasis of lung adenocarcinoma. Ning Y et al., 2021, J CancerRead more
- HIF-mediated metabolic switching in bladder outlet obstruction mitigates the relaxing effect of mitochondrial inhibition. Ekman M et al., 2014 May, Lab InvestRead more