p53 antibody
GTX128135
Overview
- SupplierGeneTex
- Product Namep53 antibody
- Delivery Days Customer9
- Application Supplier NoteWB: 1:500-1:3000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsWestern Blot
- CertificationResearch Use Only
- ClonalityPolyclonal
- Concentration1.47 mg/ml
- ConjugateUnconjugated
- Gene ID30590
- Target nametp53
- Target descriptiontumor protein p53
- Target synonymsbrp; brp53; cellular tumor antigen p53; delta113 p53; drp; drp53; etID22686.; etID22686.5; fb40d06; p5; p53; tumor suppressor p53; wu:fb40d06; zgc:111919
- HostRabbit
- IsotypeIgG
- Protein IDP79734
- Protein NameCellular tumor antigen p53
- Scientific DescriptionActs as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of bax and fas antigen expression, or by repression of Bcl-2 expression.
- ReactivityZebra Fish
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203
References
- The splicing factor DHX38 enables retinal development through safeguarding genome integrity.Read more
- Identification of the natural chalcone glycoside hydroxysafflor yellow A as a suppressor of P53 overactivation-associated hematopoietic defects.Read more
- G-protein-coupled receptor 141 mediates breast cancer proliferation and metastasis by regulating oncogenic mediators and the p-mTOR/p53 axis.Read more
- Banp regulates DNA damage response and chromosome segregation during the cell cycle in zebrafish retina.Read more
- Prpf31 is essential for the survival and differentiation of retinal progenitor cells by modulating alternative splicing. Li J et al., 2021 Feb 26, Nucleic Acids ResRead more
- Haematopoietic stem cell-dependent Notch transcription is mediated by p53 through the Histone chaperone Supt16h. Espanola SG et al., 2020 Dec, Nat Cell BiolRead more
- Tp53 Suppression Promotes Cardiomyocyte Proliferation during Zebrafish Heart Regeneration. Shoffner A et al., 2020 Sep 1, Cell RepRead more
- Estrogen and estrogen receptors chauffeur the sex-biased autophagic action in liver. Mohapatra S et al., 2020 Nov, Cell Death DifferRead more
- Ca2+ plays an antiviral role by increasing p53 expression to achieve protection against spring viraemia of carp virus infection. Lu LF et al., 2020 Jul, Fish Shellfish ImmunolRead more
- Strategy of Hepatic Metabolic Defects Induced by beclin1 Heterozygosity in Adult Zebrafish. Mawed SA et al., 2020 Feb 24, Int J Mol SciRead more