p53 antibody [HL2697]

GeneTex

p53 antibody [HL2697]

9

ImmunoHistoChemistry

Research Use Only

Monoclonal

HL2697

1 mg/ml

Unconjugated

tp53

tumor protein p53

brp; brp53; cellular tumor antigen p53; delta113 p53; drp; drp53; etID22686.; etID22686.5; fb40d06; p5; p53; tumor suppressor p53; wu:fb40d06; zgc:111919

Rabbit

IgG

Cellular tumor antigen p53

Enables DNA-binding transcription factor activity; identical protein binding activity; and sequence-specific DNA binding activity. Involved in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator and regulation of transcription by RNA polymerase II. Acts upstream of or within with a positive effect on transforming growth factor beta receptor signaling pathway involved in endodermal cell fate specification and transforming growth factor beta receptor signaling pathway involved in mesodermal cell fate specification. Acts upstream of or within several processes, including hemopoiesis; intracellular signal transduction; and regulation of nucleobase-containing compound metabolic process. Located in chromatin. Is expressed in several structures, including digestive system; head; musculature system; nervous system; and reproductive system. Used to study Li-Fraumeni syndrome; aggressive NK-cell leukemia; angiosarcoma; cancer; and malignant peripheral nerve sheath tumor. Human ortholog(s) of this gene implicated in several diseases, including Li-Fraumeni syndrome (multiple); carcinoma (multiple); hematologic cancer (multiple); open-angle glaucoma (multiple); and pancreatic cancer (multiple). Orthologous to human TP53 (tumor protein p53). [provided by Alliance of Genome Resources, Apr 2022]

Zebra Fish

-20°C or -80°C,2°C to 8°C

12352203