IHC-P analysis of Human stomach cancer tissue section using GTX00680 p53 (phospho Ser46) antibody [#36].
![WB analysis of various samples using GTX00680 p53 (phospho Ser46) antibody [#36] (upper panel) or anti-p53 antibody (lower panel). Samples : U2OS cells were irradiated by X-ray (10 Gy) for 0, 0.5, 1, 2, and 4 hrs](https://www.genetex.com/upload/website/prouct_img/normal/GTX00680/GTX00680_20191104_WB_1_w_23053121_607.webp "WB analysis of various samples using GTX00680 p53 (phospho Ser46) antibody [#36] (upper panel) or anti-p53 antibody (lower panel). Samples : U2OS cells were irradiated by X-ray (10 Gy) for 0, 0.5, 1, 2, and 4 hrs")
![WB analysis of various samples using GTX00680 p53 (phospho Ser46) antibody [#36] (upper panel) or anti-p53 antibody (lower panel). Samples : MCF-7 cells were irradiated by UV (20 J/m2) for 0, 1, 2, 4, and 8 hrs](https://www.genetex.com/upload/website/prouct_img/normal/GTX00680/GTX00680_20191104_WB_2_w_23053121_700.webp "WB analysis of various samples using GTX00680 p53 (phospho Ser46) antibody [#36] (upper panel) or anti-p53 antibody (lower panel). Samples : MCF-7 cells were irradiated by UV (20 J/m2) for 0, 1, 2, 4, and 8 hrs")
![WB analysis of MOLT-4 cells treated with/without adriamycin for 24 hrs using GTX00680 p53 (phospho Ser46) antibody [#36]. Left : GTX00680 Right : the competitors p53 phospho-Ser46 antibody](https://www.genetex.com/upload/website/prouct_img/normal/GTX00680/GTX00680_20191104_WB_w_23053121_163.webp "WB analysis of MOLT-4 cells treated with/without adriamycin for 24 hrs using GTX00680 p53 (phospho Ser46) antibody [#36]. Left : GTX00680 Right : the competitors p53 phospho-Ser46 antibody")
IHC-P analysis of Human stomach cancer tissue section using GTX00680 p53 (phospho Ser46) antibody [#36].
p53 (phospho Ser46) antibody [#36] - Comparison, Orthogonal Validated
GTX00680
ApplicationsWestern Blot, ELISA, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman
TargetTP53
Overview
- SupplierGeneTex
- Product Namep53 (phospho Ser46) antibody [#36] - Comparison, Orthogonal Validated
- Delivery Days Customer9
- ApplicationsWestern Blot, ELISA, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone ID#36
- Concentration1 mg/ml
- ConjugateUnconjugated
- Gene ID7157
- Target nameTP53
- Target descriptiontumor protein p53
- Target synonymsantigen NY-CO-13; BCC7; BMFS5; cellular tumor antigen p53; LFS1; mutant tumor protein 53; P53; p53 tumor suppressor; phosphoprotein p53; transformation-related protein 53; TRP53; tumor protein 53; tumor supressor p53
- HostMouse
- IsotypeIgG1
- Modification TypePhosphorylated
- Scientific DescriptionThis gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants (PMIDs: 12032546, 20937277). [provided by RefSeq, Dec 2016]
- ReactivityHuman
- Storage Instruction2°C to 8°C,-20°C or -80°C
- UNSPSC12352203
References
- Requirement of ATM for rapid p53 phosphorylation at Ser46 without Ser/Thr-Gln sequences. Kodama M et al., 2010 Apr, Mol Cell BiolRead more
- ATM augments nuclear stabilization of DYRK2 by inhibiting MDM2 in the apoptotic response to DNA damage. Taira N et al., 2010 Feb 12, J Biol ChemRead more
- DYRK2 is targeted to the nucleus and controls p53 via Ser46 phosphorylation in the apoptotic response to DNA damage. Taira N et al., 2007 Mar 9, Mol CellRead more