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p53 Tumor Suppressor Protein(PAb240), CF640R conjugate, 0.1mg/mL [26628-22-8]

p53 Tumor Suppressor Protein(PAb240), CF640R conjugate, 0.1mg/mL [26628-22-8]

BNC401634
Biotium
ApplicationsImmunoPrecipitation, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityBovine, Canine, Hamster, Human, Monkey, Mouse, Rat
TargetTP53
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Overview

  • Supplier
    Biotium
  • Product Name
    p53 Tumor Suppressor Protein(PAb240), CF640R conjugate, 0.1mg/mL
  • Delivery Days Customer
    9
  • Applications
    ImmunoPrecipitation, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    PAb240
  • Concentration
    0.1 mg/ml
  • Conjugate
    Other Conjugate
  • Gene ID7157
  • Target name
    TP53
  • Target description
    tumor protein p53
  • Target synonyms
    antigen NY-CO-13; BCC7; BMFS5; cellular tumor antigen p53; LFS1; mutant tumor protein 53; P53; p53 tumor suppressor; phosphoprotein p53; transformation-related protein 53; TRP53; tumor protein 53; tumor supressor p53
  • Host
    Mouse
  • Isotype
    IgG1
  • Protein IDP04637
  • Protein Name
    Cellular tumor antigen p53
  • Scientific Description
    The specificity of this monoclonal antibody to its intended target was tested by HuProt™ Array, containing more than 19,000 full-length human proteins. PAb240 binds to the C-terminus (aa213-217) of both wild type and mutated p53 in denatured samples and FFPE sections, but is reported to selectively detect mutant p53 in native samples by immunoprecipitation and ELISA. Mutation and/or allelic loss of p53 is one of the causes of a variety of mesenchymal and epithelial tumors. If it occurs in the germ line, such tumors run in families. p53 Binds to a DNA consensus sequence, the p53 response element, and it regulates normal cell growth cycle events by activating transcription of genes, involved either in progression through the cycle, or causing arrest in G1 when the genome is damaged. In most transformed and tumor cells the concentration of p53 is increased 51000 fold over the minute concentrations (1000 molecules cell) in normal cells, principally due to the increased half-life (4 h) compared to that of the wild-type (20 min). p53 Localizes in the nucleus, but is detectable at the plasma membrane during mitosis and when certain mutations modulate cytoplasmic/nuclear distribution. p53 Is the most commonly mutated gene in spontaneously occurring human cancers. Mutations arise with an average frequency of 70% but incidence varies from zero in carcinoid lung tumors to 97% in primary melanomas. High concentrations of p53 protein are transiently expressed in human epidermis and superficial dermal fibroblasts following mild ultraviolet irradiation. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
  • Source
    Animal
  • Reactivity
    Bovine, Canine, Hamster, Human, Monkey, Mouse, Rat
  • Storage Instruction
    2°C to 8°C
  • UNSPSC
    12352203