Western Blot analysis of various samples using P62/SQSTM1 Polyclonal Antibody at dilution of 1:1000.
Western Blot analysis of various samples using P62/SQSTM1 Polyclonal Antibody at dilution of 1:1000.
P62/SQSTM1 Polyclonal Antibody
E-AB-70325
Product group Antibodies
Overview
- SupplierElabscience
- Product NameP62/SQSTM1 Polyclonal Antibody
- Delivery Days Customer12
- CertificationResearch Use Only
- Scientific DescriptionSequestosome 1 (SQSTM1/p62) is a multifunctional adaptor protein implicated in selective autophagy,cell signaling pathways,and tumorigenesis. p62 has been implicated in shuttling ubiquitinated and sometimes aggregated proteins for autophagic degradation. As a autophagy-specific substrate,p62 is degraded during the autophagic process,which makes intracellular level of p62 as a marker for autophagy flux. p62 is at the cross-roads of several signaling pathways including Ras/ Raf/ MAPK and NFkappaB and plays important role in cancer. p62 is a component of inclusion bodies/ protein aggregates found in human diseases,including Huntingtons disease,Alzheimers disease,Parkinsons disease in the brain,and nephropathic cystinosis in kidney (22074114,22860231,22714671). The molecular weight of p62 is predicted as 48/ 38 kDa,while western blot analyses using this antibody demonstrate the major band around 60-62 kDa in various tissues.
- UNSPSC12352203