PABPN1 Polyclonal Antibody
RD83614A
ApplicationsWestern Blot
Product group Antibodies
ReactivityHuman, Mouse
TargetPABPN1
Overview
- SupplierReddot Biotech
- Product NamePABPN1 Polyclonal Antibody
- Delivery Days Customer5
- ApplicationsWestern Blot
- CertificationResearch Use Only
- Concentration1 mg/ml
- ConjugateUnconjugated
- Gene ID8106
- Target namePABPN1
- Target descriptionpoly(A) binding protein nuclear 1
- Target synonymsOPMD; PAB2; PABII; PABP2; PABP-2; poly(A) binding protein 2; poly(A) binding protein II; polyadenylate-binding protein 2
- HostRabbit
- IsotypeIgG
- Scientific DescriptionThis gene encodes an abundant nuclear protein that binds with high affinity to nascent poly(A) tails. The protein is required for progressive and efficient polymerization of poly(A) tails at the 3 ends of eukaryotic transcripts and controls the size of the poly(A) tail to about 250 nt. At steady-state, this protein is localized in the nucleus whereas a different poly(A) binding protein is localized in the cytoplasm. This gene contains a GCG trinucleotide repeat at the 5 end of the coding region, and expansion of this repeat from the normal 6 copies to 8-13 copies leads to autosomal dominant oculopharyngeal muscular dystrophy (OPMD) disease. Related pseudogenes have been identified on chromosomes 19 and X. Read-through transcription also exists between this gene and the neighboring upstream BCL2-like 2 (BCL2L2) gene.
- ReactivityHuman, Mouse
- Storage Instruction-20°C
- UNSPSC12352203