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Paclitaxel, from Taxus yunnanensis [33069-62-4]

Research Use Only
P0092
LKT Laboratories
Estimated Purity≥98%
Product group Chemicals
€ 563,00
100 mg
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Overview

  • Supplier
    LKT Laboratories
  • Product Name
    Paclitaxel, from Taxus yunnanensis [33069-62-4]
  • Delivery Days Customer
    7
  • Certification
    Research Use Only
  • Estimated Purity
    ≥98%
  • Format
    Insoluble in water (4 mg/L). Soluble in ethanol (18 mg/mL), DMSO (50 mg/mL).
  • Scientific Description
    Diterpene found in Taxus yunnanensis; microtubule depolymerization inhibitor.; Taxol, Taxol A, Paxene
  • Storage Instruction
    -20°C
  • UNSPSC
    12352200

References

  • Kamath K, Smiyun G, Wilson L, et al. Mechanisms of inhibition of endothelial cell migration by taxanes. Cytoskeleton (Hoboken). 2013 Oct 23. [Epub ahead of print]. PMID: 24155271. Caltová K, Cervinka M. Antiproliferative effects of selected chemotherapeutics in human ovarian cancer cell line A2780. Acta Medica (Hradec Kralove). 2012;55(3):116-24. PMID: 23297519. Jia L, Zhang S, Ye Y, et al. Paclitaxel inhibits ovarian tumor growth by inducing epithelial cancer cells to benign fibroblast-like cells. Cancer Lett. 2012 Dec 30;326(2):176-82. PMID: 22902993. Mielgo A, Torres VA, Clair K, et al. Paclitaxel promotes a caspase 8-mediated apoptosis through death effector domain association with microtubules. Oncogene. 2009 Oct 8;28(40):3551-62. PMID: 19668227. Botta M, Forli S, Magnani M, et al. Molecular modeling approaches to study the binding mode on tubulin of microtubule destabilizing and stabilizing agents. Top Curr Chem. 2009;286:279-328. PMID: 23563616. Chen YQ, Zhu WH, Wu YQ, et al. Effects of culture conditions on callus growth and taxol formation of Taxus yunnanensis Cheng et L.K.Fu. Zhongguo Zhong Yao Za Zhi. 2000 May;25(5):269-72. PMID: 12512447. Kumar N. Taxol-induced polymerization of purified tubulin. Mechanism of action. J Biol Chem. 1981 Oct 25;256(20):10435-41. PMID: 6116707. Yu YH, Kim E, Park DE, et al. Cationic solid lipid nanoparticles for co-delivery of paclitaxel and siRNA. Eur J Pharm Biopharm. 2012 Feb;80(2):268-273. PMID: 22108492.