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ProductsBack/Paclitaxel, semi-synthetic [33069-62-4]

Paclitaxel, semi-synthetic [33069-62-4]

Research Use Only
P0093
LKT Laboratories
Estimated Purity≥98%
Product group Chemicals
€ 133,00
5 mg
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Overview

  • Supplier
    LKT Laboratories
  • Product Name
    Paclitaxel, semi-synthetic [33069-62-4]
  • Delivery Days Customer
    7
  • Certification
    Research Use Only
  • Estimated Purity
    ≥98%
  • Format
    Insoluble in water (4 mg/L). Soluble in ethanol (18 mg/mL) or DMSO (50 mg/ml).
  • Scientific Description
    Semi-synthetic diterpene originally found in Taxus yunnanensis; microtubule depolymerization inhibitor.; Taxol, Taxol A, Paxene
  • Storage Instruction
    -20°C
  • UNSPSC
    12352200

References

  • Kamath K, Smiyun G, Wilson L, et al. Mechanisms of inhibition of endothelial cell migration by taxanes. Cytoskeleton (Hoboken). 2013 Oct 23. [Epub ahead of print]. PMID: 24155271. Caltová K, Cervinka M. Antiproliferative effects of selected chemotherapeutics in human ovarian cancer cell line A2780. Acta Medica (Hradec Kralove). 2012;55(3):116-24. PMID: 23297519. Jia L, Zhang S, Ye Y, et al. Paclitaxel inhibits ovarian tumor growth by inducing epithelial cancer cells to benign fibroblast-like cells. Cancer Lett. 2012 Dec 30;326(2):176-82. PMID: 22902993. Mielgo A, Torres VA, Clair K, et al. Paclitaxel promotes a caspase 8-mediated apoptosis through death effector domain association with microtubules. Oncogene. 2009 Oct 8;28(40):3551-62. PMID: 19668227. Botta M, Forli S, Magnani M, et al. Molecular modeling approaches to study the binding mode on tubulin of microtubule destabilizing and stabilizing agents. Top Curr Chem. 2009;286:279-328. PMID: 23563616 Kumar N. Taxol-induced polymerization of purified tubulin. Mechanism of action. J Biol Chem. 1981 Oct 25;256(20):10435-41. PMID: 6116707. Yu YH, Kim E, Park DE, et al. Cationic solid lipid nanoparticles for co-delivery of paclitaxel and siRNA. Eur J Pharm Biopharm. 2012 Feb;80(2):268-273. PMID: 22108492.