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Pactimibe

HY-100401
MedChem Express
CAS Number189198-30-9
Product group Chemicals
Estimated Purity99.98
Molecular Weight416.60
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Overview

  • Supplier
    MedChem Express
  • Product Name
    Pactimibe [189198-30-9]
  • Delivery Days Customer
    10
  • CAS Number
    189198-30-9
  • Estimated Purity
    99.98
  • Molecular Formula
    C25H40N2O3
  • Molecular Weight
    416.60
  • Scientific Description
    Pactimibe (CS-505 free base) is a dual ACAT1/2 inhibitor with IC 50 s of 4.9 microM and 3.0 microM, respectively. Pactimibe (CS-505 free base) inhibits ACAT with IC 50 s of 2.0 microM, 2.7 microM, 4.7 microM in the liver, macrophages and THP-1 cells, respectively [1] . Pactimibe (CS-505 free base) noncompetitively inhibits oleoyl-CoA with a K i value of 5.6 microM. Moreover, Pactimibe (CS-505 free base) obviously inhibits cholesteryl ester formation with an IC 50 of 6.7 microM. Pactimibe (CS-505 free base) possesses anti-atherosclerotic potential with lowering plasma cholesterol activity [2] .
  • SMILES
    O=C(O)CC1=C(C)C2=C(N(CCCCCCCC)CC2)C(NC(C(C)(C)C)=O)=C1C
  • Storage Instruction
    2°C to 8°C
  • UNSPSC
    12352200