Pactimibe

MedChem Express

Pactimibe [189198-30-9]

10

189198-30-9

Research Use Only

99.98

C25H40N2O3

416.60

Pactimibe (CS-505 free base) is a dual ACAT1/2 inhibitor with IC50s of 4.9 microM and 3.0 microM, respectively. Pactimibe (CS-505 free base) inhibits ACAT with IC50s of 2.0 microM, 2.7 microM, 4.7 microM in the liver, macrophages and THP-1 cells, respectively[1]. Pactimibe (CS-505 free base) noncompetitively inhibits oleoyl-CoA with a Ki value of 5.6 microM. Moreover, Pactimibe (CS-505 free base) obviously inhibits cholesteryl ester formation with an IC50 of 6.7 microM. Pactimibe (CS-505 free base) possesses anti-atherosclerotic potential with lowering plasma cholesterol activity[2].

O=C(O)CC1=C(C)C2=C(N(CCCCCCCC)CC2)C(NC(C(C)(C)C)=O)=C1C

2°C to 8°C

12352200