Pactimibe
HY-100401
Overview
- SupplierMedChem Express
- Product NamePactimibe [189198-30-9]
- Delivery Days Customer10
- CAS Number189198-30-9
- Estimated Purity99.98
- Molecular FormulaC25H40N2O3
- Molecular Weight416.60
- Scientific DescriptionPactimibe (CS-505 free base) is a dual ACAT1/2 inhibitor with IC 50 s of 4.9 microM and 3.0 microM, respectively. Pactimibe (CS-505 free base) inhibits ACAT with IC 50 s of 2.0 microM, 2.7 microM, 4.7 microM in the liver, macrophages and THP-1 cells, respectively [1] . Pactimibe (CS-505 free base) noncompetitively inhibits oleoyl-CoA with a K i value of 5.6 microM. Moreover, Pactimibe (CS-505 free base) obviously inhibits cholesteryl ester formation with an IC 50 of 6.7 microM. Pactimibe (CS-505 free base) possesses anti-atherosclerotic potential with lowering plasma cholesterol activity [2] .
- SMILESO=C(O)CC1=C(C)C2=C(N(CCCCCCCC)CC2)C(NC(C(C)(C)C)=O)=C1C
- Storage Instruction2°C to 8°C
- UNSPSC12352200