PAK1 antibody

Biorbyt

PAK1 antibody

16

Western Blot

WB:1:500-1:2000 WB

Research Use Only

Polyclonal

Unconjugated

PAK1

p21 (RAC1) activated kinase 1

alpha-PAK; IDDMSSD; p21 protein (Cdc42/Rac)-activated kinase 1; p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast); p21/Cdc42/Rac1-activated kinase 1 (yeast Ste20-related); p65-PAK; PAKalpha; serine/threonine-protein kinase PAK 1; STE20 homolog, yeast

Rabbit

Serine/threonine-protein kinase PAK 1

Rabbit polyclonal to PAK1.p21-activated kinase 1 (PAK1) belongs to the protein kinase superfamily, STE Ser/Thr protein kinasefamily and STE20 subfamily. PAK1 can be activated by CDC42 and RAC1, and is likely the GTPaseeffector that links the Rho-related GTPases to the JNK MAP kinase pathway. PAK1 is involved in thedissolution of stress fibers and reorganization of focal complexes, as well as in the regulation ofmicrotubule biogenesis through phosphorylation of TBCB. DVL1 and PAK1 form a ternary complexwith MUSK which is important for MUSK-dependent regulation of AChR clustering during theformation of the neuromuscular junction (NMJ). The activity of PAK1 is inhibited in cells undergoingapoptosis, potentially due to binding of CDC2L1 and CDC2L2.

Human, Mouse

-20°C

12352203