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Immunohistochemistry analysis of paraffin-embedded human brain tissue using PAK1/2/3 (Ab-423/402/421) antiobdy.
Immunohistochemistry analysis of paraffin-embedded human brain tissue using PAK1/2/3 (Ab-423/402/421) antiobdy.
Immunohistochemistry analysis of paraffin-embedded human brain tissue using PAK1/2/3 (Ab-423/402/421) antiobdy.

PAK1/PAK2/PAK3 (Ab-423/402/421) Antibody

Research Use Only
CSB-PA089760
Cusabio
ApplicationsWestern Blot, ELISA, ImmunoHistoChemistry
Product group Antibodies
ReactivityHuman
TargetPAK1
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Overview

  • Supplier
    Cusabio
  • Product Name
    PAK1/PAK2/PAK3 (Ab-423/402/421) Antibody
  • Delivery Days Customer
    20
  • Applications
    Western Blot, ELISA, ImmunoHistoChemistry
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Conjugate
    Unconjugated
  • Gene ID5058
  • Target name
    PAK1
  • Target description
    p21 (RAC1) activated kinase 1
  • Target synonyms
    alpha-PAK; IDDMSSD; p21 protein (Cdc42/Rac)-activated kinase 1; p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast); p21/Cdc42/Rac1-activated kinase 1 (yeast Ste20-related); p65-PAK; PAKalpha; serine/threonine-protein kinase PAK 1; STE20 homolog, yeast
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDQ13153
  • Protein Name
    Serine/threonine-protein kinase PAK 1
  • Scientific Description
    Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, or cell cycle regulation. Plays a role in dendrite spine morphogenesis as well as synapse formation and plasticity. Acts as downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration. Additionally, phosphorylates TNNI3/troponin I to modulate calcium sensitivity and relaxation kinetics of thin myofilaments. May also be involved in early neuronal development. Bernadett Boda, J. Neurosci., Dec 2004; 24: 10816 - 10825. Donna L. McPhie, J. Neurosci., Jul 2003; 23: 6914. Jin-Hun Jung, J. Biol. Chem., Dec 2005; 280: 40025 - 40031. Guo-Lei Zhou, Mol. Cell. Biol., Nov 2003; 23: 8058 - 8069.
  • Reactivity
    Human
  • Storage Instruction
    -20°C or -80°C
  • UNSPSC
    12352203