Western blot analysis of extracts from rat heart, using PAK3 (Ab-154) antibody.
Western blot analysis of extracts from rat heart, using PAK3 (Ab-154) antibody.
PAK3 (Ab-154) Antibody
CSB-PA554964
ApplicationsWestern Blot, ELISA
Product group Antibodies
ReactivityHuman
TargetPAK3
Overview
- SupplierCusabio
- Product NamePAK3 (Ab-154) Antibody
- Delivery Days Customer20
- ApplicationsWestern Blot, ELISA
- CertificationResearch Use Only
- ClonalityPolyclonal
- ConjugateUnconjugated
- Gene ID5063
- Target namePAK3
- Target descriptionp21 (RAC1) activated kinase 3
- Target synonymsadriamycin resistance-associated; ARA; beta-PAK; bPAK; MRX30; MRX47; oligophrenin-3; OPHN3; p21 (CDKN1A)-activated kinase 3; p21 protein (Cdc42/Rac)-activated kinase 3; PAK-3; PAK3beta; serine/threonine-protein kinase PAK 3; XLID30
- HostRabbit
- IsotypeIgG
- Protein IDO75914
- Protein NameSerine/threonine-protein kinase PAK 3
- Scientific DescriptionSerine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, or cell cycle regulation. Plays a role in dendrite spine morphogenesis as well as synapse formation and plasticity. Acts as downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration. Additionally, phosphorylates TNNI3/troponin I to modulate calcium sensitivity and relaxation kinetics of thin myofilaments. May also be involved in early neuronal development. Allen K.M., Nat. Genet. 20:25-30(1998). Jiang C., Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases. Kitano T., Mol. Biol. Evol. 20:1281-1289(2003).
- ReactivityHuman
- Storage Instruction-20°C or -80°C
- UNSPSC12352203