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ProductsBack/Papaverine . hydrochloride [61-25-6]
Chemical Structure
Chemical Structure
Chemical Structure

Papaverine . hydrochloride [61-25-6]

Research Use Only
AG-CN2-0414
AdipoGen Life Sciences
Estimated Purity>95% (NMR)
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Product group Chemicals
Molecular Weight339.4 . 36.5
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Overview

  • Supplier
    AdipoGen Life Sciences
  • Product Name
    Papaverine . hydrochloride [61-25-6]
  • Delivery Days Customer
    10
  • Certification
    Research Use Only
  • Estimated Purity
    >95% (NMR)
  • Hazard Information
    Non-hazardous,Warning
  • Molecular Formula
    C20H21NO4 . HCl
  • Molecular Weight
    339.4 . 36.5
  • Scientific Description
    Chemical. CAS: 61-25-6. Formula: C20H21NO4 . HCl. MW: 339.4 . 36.5. Synthetic. Originally isolated from Papaver somniferum. Smooth muscle relaxant and vasodilator. Phosphodiesterase PDE10A inhibitor. Antiviral. Antipsychotic. Potential inducer of browning in WAT. - Smooth muscle relaxant and vasodilator [4]. Phosphodiesterase PDE10A inhibitor [3,5,6]. Antiviral [1,2]. Antipsychotic [3]. Potential inducer of browning in WAT.
  • SMILES
    COC1=CC=C(CC2=NC=CC3=CC(OC)=C(OC)C=C23)C=C1OC
  • Storage Instruction
    2°C to 8°C,-20°C
  • UNSPSC
    12352200

References

  • Effect of papaverine treatment on replication of measles virus in human neural and nonneural cells: Y. Yoshikawa & K. Yamanouchi; J. Virol. 50, 489 (1984)
  • Papaverine hydrochloride: effects on HIV replication and T-lymphocyte cell function: M. Nokta, et al.; Immunopharmacol. 26, 181 (1993)
  • Inhibition of the striatum-enriched phosphodiesterase PDE10A: a novel approach to the treatment of psychosis: J.A. Siuciak, et al.; Neuropharmacol. 51, 386 (2006)
  • The effect of papaverine on ion channels in rat basilar smooth muscle cells: D.H. Han, et al.; Neurol. Res. 29, 544 (2007)
  • The PDE10A inhibitor, papaverine, differentially activates ERK in male and female rat striatal slices: Y.T. Hsu, et al.; Neuropharmacol. 61, 1275 (2011)
  • PDE10 inhibition increases GluA1 and CREB phosphorylation and improves spatial and recognition memories in a huntington's disease mouse model: A. Giralt, et al.; Hippocampus 23, 684 (2013)
  • A novel thermoregulatory role for PDE10A in mouse and human adipocytes: M.K. Hankir, et al.; EMBO Mol. Med. 8, 796 (2016)