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ProductsBack/PARG Inhibitor PDD00017273 [1945950-21-9]
Chemical Structure
Chemical Structure
Chemical Structure

PARG Inhibitor PDD00017273 [1945950-21-9]

Research Use Only
AG-CR1-3646
AdipoGen Life Sciences
CAS Number1945950-21-9
DownloadMSDS
Product group Chemicals
Estimated Purity>98%
Molecular Weight514.6
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Overview

  • Supplier
    AdipoGen Life Sciences
  • Product Name
    PARG Inhibitor PDD00017273 [1945950-21-9]
  • Delivery Days Customer
    10
  • CAS Number
    1945950-21-9
  • Certification
    Research Use Only
  • Estimated Purity
    >98%
  • Molecular Formula
    C23H26N6O4S2
  • Molecular Weight
    514.6
  • Scientific Description
    Chemical. CAS: 1945950-21-9. Formula: C23H26N6O4S2. MW: 514.6. Human poly(ADP-ribose) glycohydrolase (PARG) inhibitor for in vitro studies. Inhibits human recombinant PARG enzymes (IC50=26nM) and PARG in cell assays (IC50=37nM). Inactive against related glycohydrolases ARH3 and PARP1s (IC50>30microM). Showed no cytotoxicity (IC50>30microM). Poly(ADP ribose) glycohydrolase (PARG) is a critical component in the repair of single strand DNA breaks and therefore a target in cancer cells. PARG counteracts the function of the ARTD family of poly(ADP ribose) polymerases (known as PARPs) by efficiently catalysing the hydrolysis of O-glycosidic linkages of ADP-ribose polymer, thereby reversing the effects of PARPs. - Human poly(ADP-ribose) glycohydrolase (PARG) inhibitor for in vitro studies. Inhibits human recombinant PARG enzymes (IC50=26nM) and PARG in cell assays (IC50=37nM). Inactive against related glycohydrolases ARH3 and PARP1s (IC50>30microM). Showed no cytotoxicity (IC50>30microM). Poly(ADP ribose) glycohydrolase (PARG) is a critical component in the repair of single strand DNA breaks and therefore a target in cancer cells. PARG counteracts the function of the ARTD family of poly(ADP ribose) polymerases (known as PARPs) by efficiently catalysing the hydrolysis of O-glycosidic linkages of ADP-ribose polymer, thereby reversing the effects of PARPs.
  • SMILES
    O=C(C1=CC(S(NC2(CC2)C)(=O)=O)=CC=C1N3CC4=CC(C)=NN4C)N(CC5=CN=C(C)S5)C3=O
  • Storage Instruction
    -20°C,2°C to 8°C
  • UNSPSC
    51202000

References

  • First-in-class chemical probes against poly(ADP-ribose) glycohydrolase (PARG) inhibit DNA repair with differential pharmacology to Olaparib: D.I. James, et al.; ACS Chem. Biol. (Epub ahead of print) (2016)