PARP1-IN-12

MedChem Express

PARP1-IN-12

10

Research Use Only

C43H56FN5O5

741.93

PARP1-IN-12 is a potent PARP1 inhibitor with an IC50 of 2.99 nM. PARP1-IN-12 exhibits antiproliferative activity, can induce cell apoptosis and cause cycle arrest at G2/M phase. PARP1-IN-12 also can induce DNA double strand breaks (DSBs) in BRCA-deficient cells.

FC1=CC=C(CC(C2C=CC=CC23)=NNC3=O)C=C1C(N4CCN(CC4)C(CCCCCCCNCC5C(OC6C5C=C7[C@@](C)(C6)CCC[C@@H]7C)=O)=O)=O

See Manual

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